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CISH can be used to evaluate gene amplification, gene deletion, chromosome translocations, and chromosome number. The method utilizes conventional peroxidase or alkaline phosphatase reactions under the bright-field microscope, and is applicable to formalin-fixed, paraffin-embedded (FFPE) tissues, blood or bone marrow smears, metaphase chromosome spreads, and fixed cells. Using CISH, DAB signals can be easily viewed at 40x magnification using an ordinary light microscope, and can be archived. Simultaneous viewing of tissue morphology and gene aberration lets you avoid switching between fluorescence and light microscopes to find tumor cells of interest. There is also no need to locate the area of interest using an H&E-stained adjacent tissue section.
Available CISH products:
Amplification probes, Deletion probes, Centromeric probes, Translocation probe pairs which are brought together at the enclosed .pdf file.
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